Equipment

Our lab is integrated into the Department of Structural Biology of the Rudolf Virchow Center, headed by Prof. Caroline Kisker and Prof. Hermann Schindelin. We have state-of-the-art instrumentation for the preparation of proteins and peptides, including numerous FPLC and HPLC systems.

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A wide range of modern biophysical techniques are also available, such as

  • isothermal titration calorimetry (ITC)
  • analytical ultracentrifugation (AUC)
  • bio-layer interferometry (BLI)
  • microscale thermophoresis (MST)
  • dynamic light scattering (DLS)
  • multi-angle light scattering (MALS)
  • differential scanning calorimetry (DSC)
  • circular dichroism spectroscopy (CD)
  • fluorimetry
  • rapid mixing: quenched-flow and stopped-flow
  • mass spectrometry (ESI, MALDI, MS/MS)

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The department further provides excellent X-ray crystallographic equipment, including two  liquid dispensing robots, two in-house X-ray generators, and extensive computational resources.test30 test33 test26

We have access to the high-field NMR facility at the nearby University of Bayreuth (directed by Prof. Paul Rösch), which is the home of Germany’s first 1 GHz magnet besides 900 MHz, 700 MHz, 600 MHz,  and 400 MHz spectrometers.

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Our studies also benefit from an extensive imaging platform at the Rudolf Virchow Center that allows a wide range of microscopic applications, including atomic force microscopy (AFM) and cryo EM.